Construction of a focused ultrasound neuromodulation system for the treatment of epileptic seizure

Abstract

Ultrasound has been proved to be useful for noninvasively stimulating brain activity and has hope to play a positive role in the treatment of neurological diseases. Epilepsy is a neurological disorder in which brain activity becomes abnormal, causing seizures or periods of unusual behavior, and sometimes loss of awareness. In this paper, we established a focused ultrasound (FUS) neuromodulation system for the treatment of epilepsy. We used the chemically-induced rat epilepsy model to explore the effect of pulsed focused ultrasound on epilepsy, and obtained preliminary experimental results. We have proved the feasibility of this system through experiments, which can be used in the treatment of epilepsy by ultrasound neuromodulation.