Goal Directed Perfusion: Bibliographical Review

Abstract

Objective: The aim of this study is to synthesize the existing evidence on Goal Directed Perfusion Methods: The search for the existing evidence was made in the MEDLINE databases, using the PubMed search engine. The initial search term was “goal directed perfusion.” In order to narrow the search, MeHS terms such as “cardiac surgery” and “cardiopulmonary bypass” were used together with the initial term and the Boolean operator AND. Results: At first, 238 references were obtained, combined whit “cardiac surgery” there were 49 references and finally whit “cardiopulmonary bypass” 21. We read 23 articles. Levels of oxygen delivery (DO2i) > 272 ml/min/m2, minimize hemodilution an maintain hematocrit values > 26% decrease acute kidney injury. A carbon dioxide production VCO2 i > of 60 ml/min/m2 and DO2i/VCO2i < 5 are predictors of hyperlactatemia. The mixed venous oxygen saturation (SvO2) and the oxygen extraction rate (ERO2) are better predictors of transfusion during extracorporeal circulation than hemoglobin value. The majority of the bibliography refers to adult surgery, but the application of GDP to the pediatric perfusion is beginning. Conclusion: The improvement of “optimal” perfusion, considered the gold standard, towards goal directed perfusion is already in use. Many hospitals are incorporating online monitoring of the new perfusion parameters in order to apply a specific perfusion to each patient as well as his metabolic needs during extracorporeal circulation.