Simulation of the formation mechanism of coronary thrombosis based on DEM-CFD coupling

Abstract

Aiming at the problem of the formation of thrombosis and coronary restenosis, the formation mechanism of thrombosis was studied in this paper. The simulation model of platelet particles was established based on the theory of discrete element. And the simulation model describing the flow of blood was built based on the principle of hemodynamic. Then by means of the DEM-CFD coupling technology, a simulation model was established to describe the circumstance that platelet flows in blood. To reveal the formation mechanism of thrombosis and solve the problem of coronary restenosis, the process of blood flowing, platelet adhering to each other and to coronary stent was simulated. The result of simulation showed that blood flow velocity has a significant influence on the formation of thrombus. The result will provide basement on the cure of thrombus and the improvement of stent in the future.