PENGARUH PENGGUNAAN VARIASI KONSENTRASI AVICEL PH-101 PADA FORMULA TABLET PREDNISOLONE

Viva Medika: Jurnal Kesehatan, Kebidanan dan Keperawatan Pub Date : 2019-01-07 DOI:10.35960/vm.v10i3.446

Hilda Suherman

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Abstract

Abstract Prednisolone is a steroid class drug that is used to treat certain types of allergies, inflammatory conditions, autoimmune disorders and cancer. Solubility of prednisolone is very difficult to dissolve in water causing problems in the absorption process so that the optimum formula is needed to form Prednisolone tablets that meet the requirements of the physical properties of tablets. The purpose of this study was to make the optimum formula with a combination of lactose excipients, avicel pH-101, and amprotab to obtain prednisolone tablets with good physical properties and dissolution. Prednisolone tablets made 7 formulas with a combination of lactose (A) Avicel PH-101 (B), and Amprotab (C), Formula I (100% A); Formula II (100% B); Formula III (100% C); Formula IV (50% A + 50% B); Formula V (50% A + 50% C); Formula VI (50% B + 50% C); Formula VII (33.33% A + 33.33% B + 33.33% C) in 2 batches. The method of making prednisolone tablets by direct printing. Testing of prednisolone tablets included the physical properties of tablets, weight uniformity, uniformity in size, hardness, friability, disintegration time, and dissolution test, and content determination. Keywords: optimization of formulas, tablets, Prednisolone, Simplex Lattice Design.

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强的松龙是一种类固醇类药物，用于治疗某些类型的过敏、炎症、自身免疫性疾病和癌症。强的松龙的溶解度很难溶于水，在吸收过程中出现问题，因此需要最佳的配方来制成符合片剂物理性能要求的强的松龙片剂。本研究以乳糖为辅料、阿维索pH-101、氨protab为辅助剂，优选出物理性能和溶出度良好的强的松龙片。强的松龙片由乳糖(a)、阿维塞尔PH-101 (B)、氨protab (C)组成7个配方，配方一(100% a);式II (100% B);公式III (100% C);式IV (50% A + 50% B);式V (50% A + 50% C);式VI (50% B + 50% C);公式VII (33.33% A + 33.33% B + 33.33% C)共2批。采用直接印刷法制备强的松龙片。泼尼松龙片剂的检验包括片剂的物性、重量均匀性、粒度均匀性、硬度、脆性、崩解时间、溶出度试验和含量测定。关键词:处方优化，片剂，强的松龙，单纯形点阵设计

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Viva Medika: Jurnal Kesehatan, Kebidanan dan Keperawatan

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