SWIETENIA MAHAGONI SEEDS ATTENUATE HYPERGLYCEMIA AND PROTECT LIVER IN ALLOXAN-INDUCED DIABETIC RATS

Abstract

The present study was designed to investigate the chemical composition of Swietenia mahagoni seeds , identification of phenolic compounds in acetone extract in  mahagoni seeds, studying the fatty acids composition, and evaluation of mahagoni extracts and oil  on the glucose level of diabetes  rats. The chemical composition of seeds were moisture (3.6 %), crude fiber (14 %), ash (3%), crude protein (13 %), crude fat (7.4 %) and total carbohydrate (62.6 %). The fatty acids composition were lignoceric acid (C24) 38.23% followed by stearic acid (C18) 35.69%, meanwhile the unsaturated fatty acid was linoleic acid (C18:2), which accounted for ( 26.08 %). The phenolic compound in acetone extract showed that menthol and nerolidol are the major phenolic ( 12.32 and 10.06 % respectively ). Ttreatment with Swietenia mahagoni seed extracts and oil decreased significantly glucose level , also decreased significantly GOT , GPT , ALP , urea , creatinine and malondialdehyde level   as compared with  hyperglycemic group .