The Spastic Weakness of the Lower Extremities Fol-lowing Methadone Poisoning: A Case Report

Abstract

Background: Delayed Post-Hypoxic Leukoencephalopathy (DPHL) is a demyelinating syndrome that typically occurs in the form of progressive acute encephalopathy from a few days to weeks after apparent recovery from a coma due to prolonged cerebral hypoxia. In this article, we present a case that developed spastic weakness of the lower extremities 3 months after hypoxic coma. The patient was eventually treated following a diagnosis of DPHL.