Study on NASH mouse model with different proportions of high-fat and high-sugar diets

Abstract

: Nonalcoholic steatohepatitis (NASH) is characterized by varying degrees of steatosis, inflammatory and fibrotic changes. The pathophysiological mechanism of NASH is complex, and there is no rapid and effective method to establish Nash model. In this study, NASH mice were modeled by feeding different proportions of high-fat and high-sugar diets, and blood glucose and body weight were measured. After the modeling, HE and Masson staining were performed on the liver tissues of mice to detect the liver function, and the modeling situation of NASH on the three diets was comprehensively evaluated in combination with the liver function, which provided ideas for the development of a more rapid and effective method of NASH modeling and laid a foundation for revealing the pathogenesis of NASH.