Nonspecific Interstitial Pneumonia

Cylen Javidan-Nejad
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Abstract

Nonspecific interstitial pneumonia (NSIP) represents a less common idiopathic interstitial pneumonia than usual interstitial pneumonia (UIP) with a much better prognosis. Most cases of NSIP are secondary to collagen vascular disease, hypersensitivity or drug toxicity. These secondary forms of NSIP help to explain why it is more often seen on CT than UIP. Unlike UIP, NSIP is characterized by a paucity of honeycombing on CT and greater ground-glass opacity and reticulation. Subpleural sparing when present may suggest the diagnosis. Unlike UIP, NSIP tends to exhibit histologic spatial and temporal homogeneity. When extensive bronchiectasis is seen in association with an NSIP pattern, collagen vascular disease must be considered. When air trapping is encountered, hypersensitivity pneumonitis must be excluded. Biopsy is usually reserved for those patients with an NSIP pattern who do not have a known underlying condition. If the diagnosis of NSIP can be made, immunotherapy may prevent progression and may even reverse some CT findings.
非特异性间质性肺炎
非特异性间质性肺炎(NSIP)是一种少见的特发性间质性肺炎,其预后比通常的间质性肺炎(UIP)好得多。大多数NSIP病例继发于胶原血管疾病、过敏或药物毒性。这些继发性NSIP有助于解释为什么它在CT上比UIP更常见。与UIP不同,NSIP的特点是CT上蜂窝状斑点较少,磨玻璃不透明和网状。胸膜下保留可提示诊断。与UIP不同,NSIP倾向于表现出组织学空间和时间的同质性。当广泛的支气管扩张与NSIP模式相关时,必须考虑胶原血管疾病。当遇到空气困住时,必须排除过敏性肺炎。活检通常用于那些没有已知基础疾病的NSIP患者。如果能确诊NSIP,免疫治疗可以阻止病情发展,甚至可以逆转一些CT表现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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