Effect of administration of aqueous extracts of Securidaca longepedunculata stem barks on enzymes of the small intestine alloxan-induced diabetic rats

Proceedings of 5th International Electronic Conference on Medicinal Chemistry Pub Date : 2019-10-30 DOI:10.3390/ecmc2019-06276

Oluwaferanmi Adefolaju, Julius Arannilewa, A. Olowo

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Abstract

ABSTRACT The stem barks of Securidaca longepedunculata are used traditionally across Africa for the treatment of diabetes, cancer, metabolic diseases and asthma. This study was aimed at investigating the potential enzyme activities of the S. longepedunculata on the small intestine. Aqueous extracts of S. longepedunculata were tested in vivo on animal models: A total of 12 Wister rats were assigned into four (I–IV) groups of three animals each. Group I served as the control and was administered 0.5mL of distilled water. Groups II–IV were given 0.5, 1 and 2mg/kg body weight of S. longepedunculata stem bark extracts. The activities of the following enzymes, Alanine transaminase (ALT), Lactate dehydrogenase (LDH), Alkaline phosphatase (ALP), Aspartate transaminase (AST), were assayed in the small intestine. The result revealed a significant reduction in ALP and LDH. This gives an indication that the administration of aqueous extract of securidaca longepedunculata can elicit detrimental effect in the small intestine of the albino rat. Also the result obtained in the qualitative analysis shows the presence of phytochemicals such as: saponin, flavonoid and terpernoid.

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长柄莲茎皮水提物对四氧嘧啶诱导的糖尿病大鼠小肠酶的影响

【摘要】非洲各地传统上使用长柄Securidaca茎茎治疗糖尿病、癌症、代谢性疾病和哮喘。本研究旨在探讨长柄葡萄球菌对小肠的潜在酶活性。将12只Wister大鼠分为4 (I-IV)组，每组3只。第一组为对照组，给予蒸馏水0.5mL。ii ~ iv组分别给予长柄藤茎皮提取物0.5、1、2mg/kg体重。测定小肠内谷丙转氨酶(ALT)、乳酸脱氢酶(LDH)、碱性磷酸酶(ALP)、天冬氨酸转氨酶(AST)的活性。结果显示ALP和LDH显著降低。提示长柄棘水提物对白化大鼠小肠有不良影响。定性分析结果表明，黄酮类化合物中含有皂苷、黄酮类化合物和萜类化合物。

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Proceedings of 5th International Electronic Conference on Medicinal Chemistry

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