GET pathway mediates transfer of mislocalized tail-anchored proteins from mitochondria to the ER

S. Matsumoto, S. Ono, Saori Shinoda, Chika Kakuta, S. Okada, Takashi Ito, T. Numata, T. Endo
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引用次数: 6

Abstract

Tail-anchored (TA) membrane proteins mistargeted to mitochondria are extracted by Msp1 and then transferred to the ER for further quality control. Matsumoto, Ono, et al. show that this retransfer of mistargeted TA proteins requires the operation of the GET system.
GET途径介导错误定位的尾锚蛋白从线粒体转移到内质网
错误定位于线粒体的尾部锚定(TA)膜蛋白由Msp1提取,然后转移到内质网进行进一步的质量控制。Matsumoto、Ono等人表明,错靶TA蛋白的这种再转移需要GET系统的操作。
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