S. Matsumoto, S. Ono, Saori Shinoda, Chika Kakuta, S. Okada, Takashi Ito, T. Numata, T. Endo
{"title":"GET pathway mediates transfer of mislocalized tail-anchored proteins from mitochondria to the ER","authors":"S. Matsumoto, S. Ono, Saori Shinoda, Chika Kakuta, S. Okada, Takashi Ito, T. Numata, T. Endo","doi":"10.1083/jcb.202104076","DOIUrl":null,"url":null,"abstract":"Tail-anchored (TA) membrane proteins mistargeted to mitochondria are extracted by Msp1 and then transferred to the ER for further quality control. Matsumoto, Ono, et al. show that this retransfer of mistargeted TA proteins requires the operation of the GET system.","PeriodicalId":343306,"journal":{"name":"The Journal of Cell Biology","volume":"25 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2022-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"6","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Journal of Cell Biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1083/jcb.202104076","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 6
Abstract
Tail-anchored (TA) membrane proteins mistargeted to mitochondria are extracted by Msp1 and then transferred to the ER for further quality control. Matsumoto, Ono, et al. show that this retransfer of mistargeted TA proteins requires the operation of the GET system.