Gastrointestinal Stromal Tumor Coexistence with Multiple Myeloma: A Case Report

Abstract

Objectives: Gastrointestinal stromal tumor (GIST) is a tumor that is rarely found and is characterized by positive KIT (CD117) and DOG1 results. Multiple myeloma (MM) is characterized by malignant proliferation of uncontrolled plasma cells in the bone marrow which produces abnormal proteins in plasma or urine. The coexistence of GIST and other solid cancers in the gastrointestinal tract and urinary tract have been widely reported, but GIST coexistence with hematologic malignancies is a scarce case.Methods: Case Report. Results: Immunochemistry plays an important role in determining the diagnosis and treatment of GIST. Concomitant therapy between GIST dan MM gives good results. Conclusion: The management of both diagnoses is carried out simultaneously while considering the possibility of various side effects that arise. For GIST, given target therapy with Imatinib mesylate which is the selected target therapy, while for MM given conventional therapeutic regimens according to the patient's age and ability. In the condition of coexistence of the two types of disease, the management of the disease that most influence the quality of life with a worse prognosis, is made as the main target of initial treatment.