[Modification of lipoxygenase products in bone by the linoleic acid content of the diet].

T Bartels, G Lueddeckens, W Hein, W Förster, C Taube, M Pfeiffer, A Pfeiffer, H J Mest
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引用次数: 0

Abstract

Eicosanoids are supposed to participate in the regulation of bone metabolism. 30 male white rats of the wistar strain were fed on a diet rich in linoleic acid (LA), on a diet poor in LA and on a pellet diet after 3 month up to an age of 5 month. The formation of leukotrienes (LT) C4, D4, and E4 from the proximal tibia metaphysis after LA rich diet has been compared to the formation from LA poor and pellet diet. LA rich diet increased the formation of LTC4, D4 and E4 in the proximal tibia metaphysis. The properties of eicosanoids as local mediators in the bone were discussed.

[饲料中亚油酸含量对骨脂氧合酶产物的影响]。
类二十烷酸被认为参与骨代谢的调节。30只wistar品系雄性大鼠在3个月至5个月大时分别饲喂富含亚油酸(LA)、低亚油酸(LA)和颗粒饲料。研究人员比较了富LA日粮与低LA日粮和颗粒日粮后胫骨近端干骺端白三烯(LT) C4、D4和E4的形成情况。富含LA的饲粮增加了胫骨近端干骺端LTC4、D4和E4的形成。讨论了类二十烷酸作为骨局部介质的性质。
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