[Disorders in the systems regulating active forms of oxygen and lipoperoxidation in the skin and liver of rats following exposure to UVB-radiation].

Abstract

The effect of UV-B-radiation on the regulation of active oxygen forms and lipid peroxidation in the skin and liver of rats was investigated. It was found that UV-B-radiation of epilated skin areas (about 15% of the total body surface) of white male rats caused an increase of lipid peroxidation products (TBA-active products). In both areas, superoxide dismutase and glutathione peroxidase decreased. In the skin, these changes manifested twice--immediately and 3-5 days after exposure. In the liver, the changes were less expressed and occurred only at the time which coincided with the second wave of changes in the skin. In the skin, the pool of lipid soluble antioxidants and nonprotein thiols also decreased significantly. The latter parameter showed the highest sensitivity in the skin. Activity of glutathione reductase proved to be the most resistant parameter in the skin and liver. It is concluded that inhibition of both enzymic and nonenzymic antioxidative systems in the UV-B-irradiated organism may play an important role in the development of effects involving active oxygen forms and lipid peroxidation, especially during chronic irradiation.