Trypanosoma cruzi

Abstract

Constitutional homeophatic medicines are used to trigger reactions in the body, reducing the susceptibility morbid, while organotherapics medicines have as a principle biological identity restoring function through the homologous healthy. Aim: evaluate the effect of the constitutional medicine Lycopodium clavatum association with organotherapics of the spleen and heart of healthy mice on parasitological and clinical aspects of murine infection by Trypanosoma cruzi. Infected mices (1400 tripomastigotes-strain-Y T. cruzi) was formed according to treatment: GLB (L. clavatum and spleen’s organotherapic 13c) n=10; GLC (L. clavatum and heart’s organotherapic 13c) n=10; GLBC (L. clavatum, spleen and heart’s organotherapics 13c) n=11; GCI (7% hydroalcoholic solution, vehicle of preparation of the medicines), n=11. The total parasitaemia was significantly lower in GLBC and GLC than GCI (p<0,05). GLBC presented smaller parasitic peak than all the groups and highest pre-patent period in relation to the GCI (p<0,05). GLBC and GLB had higher temperature and body weight in relation to GCI throughout the infection (p<0,05). The increase in feed intake was significantly higher only in GLBC compared to GCI at the end of the patent period (p<0,05), showing a healthier state than the other groups. The results suggest that the associations of constitutional medicine to organotherapic made from heart and spleen, decrease the morbidity of the infection, with clinical improvement by reducing parasitism in mice infected with the Y strain of T. cruzi, which is highly pathogenic. The results encourage the use of homeopathic medicines in the treatment of Chagas' disease. * Autor Correspondente: gisajanaina@hotmail.com (G. J. Falkowski-Temporini) G. J. Falkowski-Temporini et al./ Vittalle v. 30, n. 1 (2018) 36-45