RRM designed /spl alpha/-chymotrypsin-like peptides

Abstract

The Resonant Recognition Model (RRM) has been applied to chymotrypsin to design peptides that exhibit chymotrypsin-like activity. Molecular modelling studies indicate that a 19-mer (chlida 2), which has a f/sub RRM/=0.2344 and /spl phi/=-1.186, folds appropriately so that the spatial separation of the amino acids required for chymotrypsin activity is comparable with that of /spl alpha/-chymotrypsin.