In Vitro and In Silico Study of Cytotoxicity of Metal Oxide Nanoparticles towards Escherichia coli

Proceedings of MOL2NET 2019, International Conference on Multidisciplinary Sciences, 5th edition Pub Date : 2019-11-06 DOI:10.3390/mol2net-05-06399

J. Leszczynski, S. Kar, Kavitha Pathakoti, D. Leszczyńska

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引用次数: 1

Abstract

Graphical Abstract Abstract. In continuation of study of 17 metal oxide nanoparticles (MNPs) cytotoxicity to E. coli after 2 hrs. exposure under dark conditions, we have evaluated cytotoxicity of additional 8 MNPs maintaining equivalent experiemental conditions following the literature The overall cytotoxicity ranking of these additional MNPs according to LC 50 values in descending order is Er 2 O 3 , Gd 2 O 3 , CeO 2 , Co 2 O 3 , Mn 2 O 3 , Co 3 O 4 , Fe 3 O4/WO 3 . The in vitro study clearly suggested that Er 2 O 3 and Gd 2 O 3 are the most toxic among all 25 MNPs under the mentioned experiemental conditions. The present experiemental data is one of the biggest available nano metal oxide cytotoxicity data for E. coli at present time performed under similar experimental conditions and same laboratory. Therefore, the obtained data is significant in terms of OECD principle 1 of defined endpoint to develop statistically acceptable and predictive in silico models. As two MNPs, WO 3 and Fe 3 O 4

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金属氧化物纳米颗粒对大肠杆菌细胞毒性的体外和室内研究

图形抽象抽象。继续研究17种金属氧化物纳米颗粒(MNPs)在2小时后对大肠杆菌的细胞毒性。根据LC 50值的降序排列，这些额外的MNPs的总体细胞毒性依次为er2o3、gd2o3、ceo2、co2o3、mn2o3、co2o3、co2o3、fe2o3 / wo_3。体外实验明确表明，在上述实验条件下，25种MNPs中er2o3和gd2o3毒性最大。本实验数据是目前在相同实验条件下，同一实验室获得的最大的纳米金属氧化物对大肠杆菌的细胞毒性数据之一。因此，所获得的数据在OECD原则1中具有重要意义，即定义端点以开发统计上可接受和可预测的计算机模型。作为两个MNPs, wo3和fe3o4

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Proceedings of MOL2NET 2019, International Conference on Multidisciplinary Sciences, 5th edition

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