Diagnostic value of CSF proteins assay in differential diagnosis of CNS disease

Jugoslovenska Medicinska Biohemija-yugoslav Medical Biochemistry Pub Date : 1900-01-01 DOI:10.2298/JMH0502107V

Dragana Vukosavljevic, L. Bumbaširević, A. Stefanović, M. Stojanov

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Abstract

The differential diagnosis between inflammatory and noninflammatory diseases of CNS includes CSF quantitative measurements of immunoglobulin and albumin concentrations and their comparison to the serum. For that purpose we estimated the concentrations of albumin and immunoglobulin G both in CSF and serum of patients with inflammatory and noninflammatory diseases of CNS. Parallely, these parameters were determined in the control group composed of patients having the values of investigated parameters within reference ranges. The obtained data were statistically evaluated by nonparametric Mann-Whitney test. The values of calculated CSF/albumin ratio have shown significant differences between the both patient groups and the control one (p 0.05). On the contrary, significant difference have been observed between the group with inflammatory diseases and the control (p < 0.05), proving the existence of IgG intrathecal synthesis. Values of both indexes were much higher in patients with inflammatory than noninflamatory diseases, meaning that they can be used in differential diagnosis.

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脑脊液蛋白测定在中枢神经系统疾病鉴别诊断中的价值

中枢神经系统炎症性和非炎症性疾病的鉴别诊断包括脑脊液免疫球蛋白和白蛋白浓度的定量测量及其与血清的比较。为此，我们估计了炎症性和非炎症性中枢神经系统疾病患者脑脊液和血清中白蛋白和免疫球蛋白G的浓度。与此同时，在对照组中测定这些参数，该对照组由研究参数值在参考范围内的患者组成。所得资料采用非参数Mann-Whitney检验进行统计学评价。两组脑脊液/白蛋白比值与对照组比较差异有统计学意义(p < 0.05)。相反，炎性疾病组与对照组有显著差异(p < 0.05)，证明鞘内存在IgG合成。炎症性疾病患者两项指标均高于非炎症性疾病，可用于鉴别诊断。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Jugoslovenska Medicinska Biohemija-yugoslav Medical Biochemistry

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