Exercise-induced variations in muscle tissue oxygen pressure in claudicants: effects of buflomedil.

Blood vessels Pub Date : 1991-01-01 DOI:10.1159/000158917
A M Ehrly, K Saeger-Lorenz
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引用次数: 1

Abstract

The amount of oxygen actually supplied to the ischemic muscle tissue of patients with intermittent claudication was quantified before and after a standardized pedal ergometric test. Muscle tissue pO2 was measured with micro-platin needle electrodes directly in the lower limb muscles at rest and 3, 10, 20 and 60 min after a 4-min work load. Time-dependent variations in the behavior of pO2 values as well as changes in the shapes of pooled pO2 histograms make it possible to monitor the effect of therapeutic measures. In claudicants (stage IIb) with ascertained occlusions or stenosis of the femoral artery or the pelvis region, it was demonstrated that the delayed increase in tissue pO2 after exercise could be improved by the infusion of 400 mg buflomedil. Comparison between the time-related pooled histograms confirmed improvement of oxygen supply under the influence of this drug.

运动引起的肌肉组织氧压变化:丁咯地尔的作用。
对间歇性跛行患者缺血肌肉组织的实际供氧量进行了标准化踏板测功测试前后的量化。在休息和4分钟负荷后3、10、20和60分钟,用微铂针电极直接在下肢肌肉中测量肌肉组织pO2。pO2值的行为随时间的变化以及pO2直方图形状的变化使得监测治疗措施的效果成为可能。在确定有股动脉或骨盆区域闭塞或狭窄的跛行患者(IIb期)中,运动后组织pO2的延迟增加可以通过输注400mg丁氟地尔来改善。时间相关的汇总直方图的比较证实了在该药的影响下氧供应的改善。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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