Lensed fiber-optic scanning two-photon endomicroscopic imaging

Abstract

In recent years, two-photon endomicroscopy has developed as a promising label-free optical biopsy technique for diagnosing gastrointestinal tumors. In this study, we optimize the imaging resolution of the lensed fiber-optic scanning two-photon endomicroscopic imaging scheme. By fabricating a lensed fiber for fiber-optic scanning two-photon endomicroscopy, a lateral resolution of 2.1 μm and a field of view of 600 μm in two-photon endomicroscopic imaging is achieved. Furthermore, the objective-lens-free imaging capability is also validated using gastric