PEG-Mediated Green One Pot Synthesis by Using Click Chemistry

Abstract

The regioselective synthesis of 1,4-disubstituted 1,2,3-triazoles derivatives from substituted alkynes and organic halides with sodium azide by using CuI catalyst in polyethylene glycol-400 as a green reaction media. This process is of considerable synthetic advantages in terms of green principles, high atom economy, low environ-mental impact, mild reaction condition, high purity and good yields. We find out the use of eco-friendly solvent like mixture of PEG-400 and water for the synthesis of 1,2,3-triazole. The main aim of this research is to found the method which required very short time, cost effective, feasible and a green method as compared to known reported for synthesis of 1,2,3-triazole as a medicinally important scaffold by click chemistry.