Anti-Glomerular Basement Membrane Disease Following Nephrectomy

Abstract

A 51 year old female presented with rapidly progressive renal failure and diffuse alveolar hemorrhage following nephrectomy for retroperitoneal fibrosis. Anti-glomerular basement membrane (anti-GBM) antibodies returned strongly positive confirming a diagnosis of anti-GBM disease. She was treated with corticosteroids, plasma exchange and cyclophosphamide. To our knowledge, this is the first adult case of anti-GBM disease following nephrectomy.