[The use of the perfused rat heart as a model for selecting antihypoxic compounds].

Farmakologiia i toksikologiia Pub Date : 1991-05-01
A A Korneev, G A Sheveleva
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Abstract

The test system for selection of antihypoxic compounds was developed and approved on the basis of the model of the perfused rat heart. It was found that the hypoxic state of the moderate degree of severity simulated on the myocardium is optimal for the assessment of the studied antihypoxic compounds. Taking into consideration the fact that at the early stages of hypoxia the electron transport is disordered at the level of the first enzymatic complex of the respiration chain, the protective actions of the agents (menadione and hydroquinone) being able of shunting the respiration chain to bypass the damaged area were studied. It was found that under hypoxia these compounds improve the energy-dependent contractile properties of the myocardium, that is, show up the antihypoxic effects.

[用灌注的大鼠心脏作为选择抗缺氧化合物的模型]。
在大鼠灌注心脏模型的基础上,研制并批准了抗缺氧化合物筛选试验系统。研究发现,心肌模拟中等程度的缺氧状态是评估所研究的抗缺氧化合物的最佳条件。考虑到在缺氧的早期阶段,电子传递在呼吸链的第一酶复合物水平上是紊乱的,研究了能够分流呼吸链以绕过受损区域的药物(甲萘醌和对苯二酚)的保护作用。发现在缺氧条件下,这些化合物能改善心肌的能量依赖性收缩特性,即表现出抗缺氧作用。
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