Effect of age on rabbit aortic responses to relaxant endothelium-dependent and endothelium-independent agents.

Blood vessels Pub Date : 1991-01-01 DOI:10.1159/000158882

A Chinellato, L Pandolfo, E Ragazzi, M R Zambonin, G Froldi, M De Biasi, L Caparrotta, G Fassina

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引用次数: 29

Abstract

The aim of this study was to evaluate the effects of aging on endothelium-dependent and endothelium-independent relaxation of rabbit thoracic aorta from New Zealand white rabbits aged 4-6 and 7-12 months. The contractile response to noradrenaline (NA) decreased with increasing age, but NA [EC50] did not vary significantly. Acetylcholine (Ach)-induced relaxation of aortic rings precontracted with NA [EC50] did not change significantly with increasing age. The relaxation induced by ATP of aortic rings, precontracted with NA [EC50], was significantly greater in young than in adult rabbits. This difference between young and adult animals became more evident in aortic rings deprived of endothelium: in adult animals, the ATP-induced relaxation of aortic rings with endothelium was significantly greater than in the rings without endothelium. The endothelium-independent relaxation by sodium nitrite (NaNO2) at lower concentrations was significantly greater in young than in adult rabbit aortic rings precontracted with NA [EC50]. Concluding, the age-induced changes in vascular response in male New Zealand white rabbits are related to an impaired mechanism at smooth muscle level.

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年龄对兔主动脉对舒张性内皮依赖性和非内皮依赖性药物反应的影响。

本研究以4 ~ 6月龄和7 ~ 12月龄新西兰大白兔为研究对象，观察衰老对兔胸主动脉内皮依赖性松弛和内皮非依赖性松弛的影响。去甲肾上腺素(NA)的收缩反应随年龄的增加而降低，但NA [EC50]无显著差异。乙酰胆碱(Acetylcholine, Ach)诱导的NA预收缩主动脉环舒张[EC50]不随年龄的增加而发生显著变化。ATP诱导的NA预收缩主动脉环的松弛[EC50]在幼兔中明显大于成年兔。这种差异在年轻动物和成年动物的主动脉环中变得更加明显:在成年动物中，有内皮的主动脉环的atp诱导的松弛明显大于没有内皮的主动脉环。低浓度亚硝酸钠(NaNO2)对幼兔主动脉环的内皮非依赖性松弛作用明显大于经NA预收缩的成年兔[EC50]。综上所述，年龄引起的雄性新西兰大白兔血管反应变化与平滑肌水平的受损机制有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Blood vessels

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