Diuretic effect of Trigonella foenum graecum seed extracts

Abstract

Purpose: Trigonella foenum-Graceum Linn commonly known as fenugreek has a long history of traditional use in ayurveda and Chinese medicine and has been used for numerous indications, including labor induction, aiding digestion and to improve metabolism and diuresis. The present study was to evaluate the diuretic activity as traditionally claimed, from successive petroleum ether, benzene, ethanol and aqueous extract of fenugreek seed. Method: The diuretic activity of the successive extract of fenugreek seeds was investigated in wistar rat, according to Lipschitz method. Phytochemical analyses of the extracts were carried out. The Na+, K+ ion concentrations were estimated by flame photometer, and Cl ion concentration was estimated by titration against silver nitrate. Results: The diuretic response and electrolyte excretion potency from petroleum ether, and benzene extract were remarkable in comparison with the control animals. The extract at 150 and 350 mg/kg body weight showed a dose dependent increase in volume of urine, the naliuretic activity seen by increase in Na +/ K+ ions ratio with respect to control. Conclusion: The study indicates that aqueous and benzene extract as an effective diuretic and naluretic; thus, the work supports the traditional claim about the fenugreek seeds being used as diuretic.