Action Of The Proteasome Activator REGγ In Autoimmune Diseases

Abstract

disease with multiple systems and organs damaged [1]. Lupus Nephritis (LN) is one of the most serious complications in SLE and almost all SLE patients have varying degrees of renal lesions which directly affect the prognosis of SLE [2]. About 60% of SLE patients have LN, and 10%~30% of patients eventually develop renal failure [3]. The pathogenesis of SLE is complex and has yet to be clearly explained, resulting in a lack of effective targeted therapy in clinical practice.