A ready-to-use dose-response model of Campylobacter jejuni implemented in the FSKX-standard

Esther M. Sundermann, Maarten Nauta, A. Swart
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Abstract

Dose-response models are an important part of quantitative microbiological risk assessments. In this paper, we present a transparent and ready-to-use version of a published dose-response model that estimates the probability of infection and illness after the consumption of a meal that is contaminated with the pathogen Campylobacter jejuni. To this end, model and metadata are implemented in the fskx-standard. The model parameter values are based on data from a set of different studies on the infectivity and pathogenicity of Campylobacter jejuni. Both, challenge studies and outbreaks are considered, users can decide which of these is most suitable for their purpose. We present examples of results for typical ingested doses and demonstrate the utility of our ready-to-use model re-implementation by supplying an executable model embedded in this manuscript.
在fskx标准中实施的空肠弯曲杆菌即用型剂量-反应模型
剂量-反应模型是定量微生物风险评估的重要组成部分。在这篇论文中,我们提出了一个透明的和现成的版本的已发表的剂量反应模型,估计感染和疾病的概率后,被病原体空肠弯曲杆菌污染的膳食消费。为此,在fskx标准中实现了模型和元数据。模型参数值是基于一系列关于空肠弯曲杆菌的传染性和致病性的不同研究的数据。考虑到挑战研究和疫情暴发,用户可以决定哪一个最适合他们的目的。我们给出了典型摄入剂量的结果示例,并通过提供嵌入在本文中的可执行模型来演示我们的即用型模型重新实现的实用性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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