FEATURES OF RESISTANCE TO HYPOXIA IN ELDERLY PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Ukrainian Pulmonology Journal Pub Date : 1900-01-01 DOI:10.31215/2306-4927-2021-29-3-36-40

E. Asanov, Y. Golubova, I. Dyba, S. Asanova

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Abstract

FEATURES OF RESISTANCE TO HYPOXIA IN ELDERLY PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE E. O. Asanov, Yu. I. Golubova, I. A. Dyba, S. O. Asanova Abstract Aim: to study the features of resistance to hypoxia in elderly patients with COPD. Material and methods. We examined 46 elderly patients with COPD and 18 apparently healthy elderly people. Hypoxia resistance was determined by performing a hypoxic test with inhalation of 12 % O2 for 20 minutes. The state of ventilation and blood saturation were assessed. Results. Hypoxia caused the reduction of SpO2 and the development of arterial hypoxemia in elderly patients with COPD, which were more significant than in healthy elderly people. It was found that among elderly patients with COPD and healthy elderly subjects there were people with preserved and reduced resistance to hypoxia. However, reduced resistance to hypoxia was much more common in elderly patients with COPD. Decreased resistance to hypoxia in elderly patients with COPD was associated with the degree of bronchial obstruction: deterioration of bronchial passability led to reduced resistance to hypoxia. Elderly patients with COPD with reduced resistance to hypoxia had a decrease in the ΔVE/ ΔSpO2 ratio and a slow ventilation response to hypoxic exposure. Conclusions. Among healthy elderly people and elderly patients with COPD there were subjects with reduced and preserved resistance to hypoxia. Decreased resistance to hypoxia was much more common in elderly patients with COPD. Decreased resistance to hypoxia was more common in patients with moderate than mild bronchial obstruction. Elderly patients with COPD with reduced resistance to hypoxia had reduced ventilation response to hypoxia and chemoreflex sensitivity. Key words: COPD, older age, resistance to hypoxia, ventilation, saturation. Ukr. Pulmonol. J. 2021;29(3):36–40:

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老年慢性阻塞性肺疾病患者的缺氧抵抗特征

老年慢性阻塞性肺疾病患者对缺氧的抵抗特点摘要目的:探讨老年COPD患者的缺氧抵抗特点。材料和方法。我们检查了46例老年COPD患者和18例表面健康的老年人。通过吸入12% O2 20分钟进行缺氧试验来测定耐缺氧性。评估通气状态和血饱和度。结果。低氧导致老年COPD患者SpO2降低和动脉低氧血症的发生，且较健康老年人更为显著。发现老年COPD患者和健康老年受试者中存在缺氧抵抗力保留和降低的人群。然而，对缺氧的抵抗力降低在老年COPD患者中更为常见。老年COPD患者缺氧抵抗能力下降与支气管阻塞程度相关:支气管通过性恶化导致缺氧抵抗能力下降。老年COPD患者缺氧抵抗力降低，其ΔVE/ ΔSpO2比值降低，缺氧暴露时通气反应缓慢。结论。在健康老年人和老年慢性阻塞性肺病患者中，有低氧抵抗能力降低和保持的受试者。低氧抵抗能力下降在老年COPD患者中更为常见。对缺氧的抵抗力下降在中度支气管阻塞患者中比轻度支气管阻塞患者更常见。老年COPD伴低氧抵抗降低的患者缺氧通气反应和化疗反射敏感性降低。关键词:慢性阻塞性肺病，老年，抗缺氧，通气，饱和度。Ukr。Pulmonol。j . 2021;(3): 29日36-40:

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Ukrainian Pulmonology Journal

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