Preliminary clinical application of radioimmunoimaging of breast cancer using ~(99)Tc~m labeled anti-mucin monoclonal antibody

Abstract

Objective To evaluate the clinical value of radioimmunoimaging (RII) in diagnosis of breast cancer using 99Tcm labeled anti­mucin monoclonal antibody. Methods 17 patients with various breast tumors underwent RII. Results 8 of 9 patients with primary breast cancer gave positive results of RII, with the sensitivity of 88.89%. Ipsilateral lymphatic metastasis was detected in 4 of 5 patients with primary breast cancer plus axillary lymph node involvement and for the remaining 1 patient contralateral lymph node metastasis was detected; the patient received mastectomy 5 years ago due to breast cancer of that side. RII results of the remaining 7 patients were negative, they were 6 patients with benign breast tumour and 1 followed­up patient who underwent mastectomy 7 years ago due to breast cancer. Conclusions RII using 99Tcm labeled anti­mucin McAb can be used as a valuable method in the diagnosis of primary breast cancer, lymph node metastases and recurrence. Key words: Antibodies, monoclonal; Antibodies, neoplasm; Mucins; Breast neoplasms; Radioimmunodetection