Epithelial cell plasticity in neoplasia.

IF 3.5 Q1 DENTISTRY, ORAL SURGERY & MEDICINE
J Jouanneau, G C Tucker, B Boyer, A M Vallés, J P Thiery
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Abstract

Tumor metastasis is associated with an increase in the plasticity of malignant cells, a phenomenon that is characterized by changes in cell morphology and a decrease in intercellular cohesiveness. The plasticity of cells is correlated with their motility. Therefore, factors that enhance plasticity promote the migration of malignant cells from a primary tumor. Several cytokines that induce the dissociation and dispersal of malignant cells have now been described. By inhibiting the activity of motogenic cytokines, it may be possible to design effective strategies for the treatment of patients with metastatic cancer.

肿瘤中上皮细胞的可塑性。
肿瘤转移与恶性细胞可塑性的增加有关,这种现象的特征是细胞形态的改变和细胞间凝聚力的降低。细胞的可塑性与其运动性有关。因此,增强可塑性的因素促进了恶性细胞从原发肿瘤的迁移。现在已经描述了几种诱导恶性细胞分离和扩散的细胞因子。通过抑制运动因子的活性,有可能设计出有效的策略来治疗转移性癌症患者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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