[Dynamic biochemical, metrometric and histomorphological studies in isoproterenol-induced myocardial hypertrophy and its regression in rats].

K Prodanov, R Kolarova, L Tsakova, M Balutsov
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Abstract

Isoproterenol, administered intraperitoneally in rats in a dose of 2 mg/kg of body mass for a period of 20 days, induced myocardial hypertrophy. After its stoppage a period of regression occurred, during which the myocardium recovered practically to its initial state. Complex studies of connective-tissue components (collagen, glycosaminoglycans, total nonfibrillary protein, total protein, structural, glycoproteins), metrometric data-the coefficient R (1 g of myocardium/199 g of body mass) and histomorphological investigations were performed. The same studies were done on rats of a control nontreated group and of experimental groups-on the 0 day. 7th, 14th and 42 day. It was established there was a gradual recovery to normal values of collagen, total nonfibrillary protein and the coefficient R, which were highest on the day 0. Progressive diminution, e.g., normalization of both the connective tissue components and of the volume of myocardial cells was found histomorphologically, in which the changes were mostly manifested on the day 0, as well. The complex studies of the connective tissue with isoproterenol MH proved that the changes of MH in this tissue correlated with the stages of MH respectively its regression.

异丙肾上腺素诱导大鼠心肌肥大及其消退的动态生化、计量和组织形态学研究。
异丙肾上腺素按2 mg/kg体重腹腔注射,连续20天诱导心肌肥厚。心肌停止后,出现一段退行期,在此期间心肌几乎恢复到其初始状态。结缔组织成分(胶原蛋白、糖胺聚糖、总非纤维蛋白、总蛋白、结构蛋白、糖蛋白)的复杂研究,计量数据-系数R (1 g心肌/199 g体重)和组织形态学调查。在第0天,对未治疗组和实验组的大鼠进行了同样的研究。第7、14、42天。胶原蛋白、总非纤维蛋白和R系数逐渐恢复到正常水平,在第0天达到最高值。组织学上发现结缔组织成分和心肌细胞体积逐渐减少,如恢复正常,这种变化也主要表现在第0天。对异丙肾上腺素MH结缔组织的复杂研究证明,该组织中MH的变化与MH各自的消退阶段相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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