Application of activated conditioned plasma in patients with macular rupture

Abstract

Objective. To evaluate and summarize the results, as well as to conduct a comparative analysis of the treatment of patients with macular rupture with autoplasm, using a Rotofix 32A Centrifuge and Arthrex ACP systems to obtain autologous conditioned plasma (АСР) with previously used surgical methods. Material and methods. The study conducted a comparative analysis of the results of treatment of patients with macular rupture, with a corrected visual acuity of more than 0.08 (according to the Golovin–Sivtsev table). Group 1 (prospective analysis) included the results of treatment using peeling of the inner boundary membrane with a gas/air tamponade in combination with the application of AСР (4 eyes, 4 patients). In the 2nd group (retrospective analysis of the medical history), surgical treatment was limited to the peeling of the inner boundary membrane with a gas/air tamponade (8 eyes, 8 patients). The parameters were analyzed after 3.0±0.5 and 6.0±0.5 months with assessment of maximum corrected visual acuity (MCOZ), optical coherence tomography (OCT), color photography. Closure of the macular gap was assessed at 6 months of follow-up when comparing the groups. Results. No complications were detected in both groups during the observation period. According to visometry and OCT data, the best functional results were obtained in group 1. The average visual acuity after 6 months was 0.4±0.1. Conclusion. The study found that the use of the peeling of the inner boundary membrane with gas/air tamponade and the use of platelet-derived mass increased the probability of rupture closure.