Laboratory treatment of Trypanosoma evansi - infected rats with a combination of Securidaca longepedunculata and Diminazene aceturate

Abstract

Trypanocidal potency of Securidacalongepedunculata (violet tree), a common savannah shrub with broad spectrum medicinal use throughout tropical Africa was compared and combined with Diminazene aceturate (Berenil ®), a standard but toxic and costly trypanocidal drug. Subsequently, various experimental groups of laboratory maintained Wister albino rats, were infected with stocked T. evansi and thereafter given, as soon as parasitaemia was established, intra-peritoneal injections of separate or combined doses of Bereni ® and/or 40.6% yield of the dried crude root extract of oral Securidaca respectively. The result showed that sub-therapeutic doses of the combined Bereni ® (1.7 mg/kg) and Securidaca (100 mg/kg), was as good as therapeutic doses (3.5 mg/kg) of Berenil ® alone, at significantly (p Animal Production Research Avancees Vol. 3 (1) 2007: pp. 38-42