Expression of fas protein on CD4+ T cells irradiated by low level He-Ne laser in the case of psoriasis

Abstract

Objective: To investigate the influence on the Expression of Fas protein on CD4+ T cells irradiated by low level He-Ne laser in the cases of psoriasis. Methods: the expression of CD4+ T Fas protein was determined in the case of psoriasis (n=5) pre and post-low level laser irradiation (30 min, 60min and 120min) by flow cytometry as compared withthe control (n=5). Results: In the cases of psoriasis, the expression of CD4+ T FAS protein 21.4±3.1% was increased significantly than that of control group 16.8±2.1% pre-irradiation, p<0.05; in the control, there is no difference between pre and post- irradiation, p>0.05; in the cases, the expression of CD4+ T Fas protein wae positively corelated to the irradiation times, when the energy density arrived to 22.92J/cm2 (60 minutes) and 45.84J/cm2 (120minutes), the expression of CD4+ T Fas protein was increased significantly as compared with pre-irradiation, p<0.05. Conclusion: The expression of CD4+ T Fas protein may be increased by low level He-Ne laser irradiation, the uncontrolled status of apoptosis could be corrected.