[The effect of a chemotherapeutical amine containing toothpaste on plaque formation, gingivitis and caries in clinical and animal experiment].

Abstract

"C31G" means and amine mixture, which shall be, a new "sure" substance of small toxicity and is used as an effective plaque and caries reducing chemotherapeutical substance in a tooth paste. In this study we report on: the caries reducing effect in the teeth cleaning experiment in Osborn-Mendel-rats (96 animals, 6 Groups) with C-31G-containing tooth pastes in different concentrations and also in combinations with and without fluoride. the effect of an 1% C31G-containing tooth paste on plaque formation (SLI + QHI) and gingivitis (SBI) in a clinical double blind cross over-study (section % patients, 2 groups, 2 pre-experimental OH-Plases, teeth cleaning once per day). The study results don't show the expected plaque and caries reducind effect. The results of the in vivo and in vitro experiments call for a critical examination of the substances with attention of further parameters.