CONCENTRATION OF POTASSIUM IONS IN THE SPERM CAN BE CONSIDERED A DETERMINANT OF CLINICAL EFFECTIVENESS OF PUMPKIN SEED OIL IN PATIENTS WITH CHRONIC PROSTATITIS 3B

Abstract

Background. For objective assessment of the functional status of prostatic tissue, the «Kalium Parameter of Laboratory analysis, Evaluating in Ejaculate (KAPLEE)» was offered. KAPLEE is the concentration of K+ ions, measuring with the help of potentiometry in 42 ml of water solution, which contains 1 ml of ejaculate, 39 ml of distilled water and 2 ml of special buffer solution. The aim: to check the hypothesis that the deviation of KAPLEE from the normal range towards reduction or towards increase is the determinant of less efficacy of pumpkin seed oil (PSO) in patients with chronic prostatitis 3B (CP3B). Materials and methods: In trial 51 patients with the diagnosis of CP3B, who received PSO 5400 mg a day (4 capsules 3 times a day) for 30 days as monotherapy, took part. The study included 2 stages. During first stage each patient evaluated the efficacy of this pharmacotherapy in his case; it varied from 1 point (absolute non-efficacy) to 5 points (absolute efficacy). Then each patient ejaculated into container, and the concentration of KAPLEE was measured. Thus, the data of each patient were placed in two-axial system of coordinates: axis of abscisses was the concentration of KAPLEE, axis of ordinates was the mark of efficacy. Then the cluster analysis of these data was made. Results and conclusion. Concentration of potassium ions in the sperm can be considered a determinant of clinical effectiveness of pumpkin seed oil in patients with chronic prostatitis.