[Comparison of pharmacokinetic parameters of tetracyclines which are most frequently used in veterinary medicine].

Abstract

40 adult White Californian rabbits were monitored for serum levels, soft tissue concentrations, and biological half-life of technical chlorotetracycline (Aureovit 12 C40 -- SPOFA), chlorotetracycline chloride (Farmitalia substance), tetracycline chloride (tetramyocine tablets for veterinary use -- SPOFA), and oxytetracycline chloride (oxymycoine in powder form for solution for veterinary use -- SPOFA), following application of 20 micrograms.kg-1. All tetracyclines tested were orally administered by gavage, following dissolution or suspension (Aureovit 12 C40). Statistically significant differences were found to exist among serum levels of various tetracyclines, with the 1st to 11th hours from administration, whereafter differences turned minimal between the 11th and 24th hours. Differences were found to exist also among concentrations in various organs.