Action of an Indolinone Derivative on Plasma Hemostasis

Abstract

The action of a new pharmaceutical substance of indolinone series, an sGC inducer with antiplatelet activity, on rat blood plasma hemostasis was studied. It was shown that the antiplatelet substance after single oral administration to rats considerably increases thrombin time after 3 hours (24.5 versus 17.3 in control, р <0.05). Other plasma hemostasis parameters were unchanged.