piRNAtarget: The Integrated Database for Mining Functionality of piRNA and Its Targets

2016 IEEE 16th International Conference on Bioinformatics and Bioengineering (BIBE) Pub Date : 2016-10-01 DOI:10.1109/BIBE.2016.64

B. Jiang, Wanyi Wu, Ching-Hsuan Chien, J. Tsai, Wen-Ling Chan

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引用次数: 3

Abstract

PIWI-interacting RNAs are a class of small RNA (sRNA) distinct from microRNA (miRNA) in sequence length and conservation structure. The recently report indicated that human piRNAs not only expressed in germline but also detected in somatic tissues. They interact with piwi-clade Argonauts (Ago), as well as sequences complement with transposons and target genes to effect epigenetic and post-transcriptional regulation. Additionally, piRNAs are involved in DNA methylation and cancer development. Investigation into the mechanism of piRNAs is an important and rapidly growing issue of research. In this study, we constructed an integrated database, piRNAtarget, for studying the functionality of piRNA and its targets. This database includes a variety of information, such as annotations, sequences, parental genes, targets, expression, mutation and methylation profiles in human piRNAs. We believe that piRNAtarget will contribute to a better understanding of the human piRNA functions. piRNAtarget is freely accessible and available at: http://120.108.102.11/~sophia/piRNAtarget.

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piRNAtarget:用于挖掘piRNA及其目标功能的集成数据库

piwi相互作用RNA是一类与microRNA (miRNA)在序列长度和保守结构上不同的小RNA (sRNA)。最近的报道表明，人类pirna不仅在种系中表达，而且在体细胞组织中也能检测到。它们与piwi-枝argonaut (Ago)相互作用，并与转座子和靶基因互补，以影响表观遗传和转录后调控。此外，pirna还参与DNA甲基化和癌症的发展。研究pirna的作用机制是一个重要而迅速发展的研究课题。在这项研究中，我们构建了一个集成数据库piRNAtarget，用于研究piRNA及其靶点的功能。该数据库包括各种信息，如人类pirna的注释、序列、亲本基因、靶标、表达、突变和甲基化谱。我们相信piRNAtarget将有助于更好地了解人类piRNA的功能。piRNAtarget可以在http://120.108.102.11/~sophia/piRNAtarget免费获取。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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2016 IEEE 16th International Conference on Bioinformatics and Bioengineering (BIBE)

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