Preparation and Characterization of Pulmonary Surfactant-Super Oxide Dismutase Liposomes

Abstract

Objective: To prepare pulmonary surfactant-superoxide dismutase (PS-SOD) Liposomes and analyze the biological characteristics of them. Methods: To prepare PS-SOD Liposomes with rotary evaporation method and analyze the formulation and bioactivity of them, including shape, size, encapsulating ratio, antioxidant activity and surface tension. Results: The PS-SOD Liposome is a kind of ivory white suspension and presents to be a fairly homogeneous spherical article with a mean grain size of 0.463±0.223μm. There is no change in antioxidant activity before and after SOD being encapsulated to be PS-SOD Liposomes. No difference has been found in surface tension between PS and PS-SOD Liposomes. Conclusion: PS-SOD Liposomes can be successfully prepared through rotary evaporation method and maintain stable biological activities both of PS and SOD. Source of financial support: National Natural Science Foundation of China, NO.30471714;