Use of Intraventricular Vancomycin in Neonatal Meningitis Dueto Elizabethkingilla Meningoseptica

Abstract

Elizabethkingia meningoseptica is a non-motile, catalase positive, oxidase positive, non-glucose fermenting, gram negative bacilli which is resistant to common drugs active against gram negative organism. It presents as neonatal meningitis mostly in preterms as they have low immunity. Antibiotics which have shown effectiveness against this organism includes cefepime, tazobactam, piperacillin, cotrimoxazole, tigecycline, minocycline, quinolones and drugs active against gram positive bacteria such as vancomycin and rifampicin. Intraventricular therapy use has been limited owing to drug toxic effect. Seizures, hearing loss and chemical ventriculitis had been reported mostly as short term side effect. Long term side effect needs more follow up studies. Here we report a preterm newborn having E.meningoseptica ventriculitis showing improvement with intraventricular vancomycin without any short term adverse effect in first 6 months of life.