Design and freeform fabrication of load bearing tissue scaffolds

B. Starly, L. Shor, Z. Fang, W. Sun
{"title":"Design and freeform fabrication of load bearing tissue scaffolds","authors":"B. Starly, L. Shor, Z. Fang, W. Sun","doi":"10.1109/NEBC.2005.1431974","DOIUrl":null,"url":null,"abstract":"Scaffolds with designed interior pore architecture, predefined porosity and a well interconnected predetermined network has been the most favored design approach for tissue engineering applications. This paper will present the details of our development in the design and fabrication of biomimetic tissue scaffolds based on tissue requirements. This includes the 3D reconstruction of patient-specific medical imaging data (CT/MRI), the evaluation of tissue properties, the incorporation of intended biophysical and biological requirements into the design model, and the characterization of designed scaffold mechanical properties. The paper also presents a novel design approach to generate the designed scaffolds using layered freeform fabrication without forming complicated 3D CAD scaffold models. Feasibility studies applying the algorithm to example models and the generation of fabrication planning instructions involving heterogeneous structures will also be presented.","PeriodicalId":256365,"journal":{"name":"Proceedings of the IEEE 31st Annual Northeast Bioengineering Conference, 2005.","volume":"1 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2005-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Proceedings of the IEEE 31st Annual Northeast Bioengineering Conference, 2005.","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/NEBC.2005.1431974","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2

Abstract

Scaffolds with designed interior pore architecture, predefined porosity and a well interconnected predetermined network has been the most favored design approach for tissue engineering applications. This paper will present the details of our development in the design and fabrication of biomimetic tissue scaffolds based on tissue requirements. This includes the 3D reconstruction of patient-specific medical imaging data (CT/MRI), the evaluation of tissue properties, the incorporation of intended biophysical and biological requirements into the design model, and the characterization of designed scaffold mechanical properties. The paper also presents a novel design approach to generate the designed scaffolds using layered freeform fabrication without forming complicated 3D CAD scaffold models. Feasibility studies applying the algorithm to example models and the generation of fabrication planning instructions involving heterogeneous structures will also be presented.
承载组织支架的设计和自由成形
具有预先设计的内部孔隙结构、预先确定的孔隙度和良好互连的预先确定的网络的支架是组织工程应用中最受欢迎的设计方法。本文将详细介绍我们在基于组织需求的仿生组织支架的设计和制造方面的进展。这包括患者特异性医学成像数据(CT/MRI)的3D重建,组织特性的评估,将预期的生物物理和生物学要求纳入设计模型,以及设计支架机械特性的表征。本文还提出了一种新颖的设计方法,采用分层自由形状制造方法生成所设计的支架,而无需生成复杂的3D CAD支架模型。将该算法应用于实例模型的可行性研究以及涉及异质结构的制造规划指令的生成也将被提出。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信