Signaling Pathway Genetic Variations in Apical Periodontitis

Abstract

A better understanding of gene expression and variation in signaling pathways in apical periodontitis has resulted in identifying the host response and new therapeutic targets for inflammatory diseases. Inflammatory mediators can reduce cell signaling, interfering with transcription factor activation and inflammatory gene expression. In apical periodontitis (AP), genetic studies focusing on the host response and signaling pathways can establish a link between specific possible genes and the disease. The purpose of this review is to provide information on host response and genetic variations in major apical periodontitis signaling pathways.