Treatment of non-small cell lung cancer using radiation therapy

Abstract

The article is devoted to the use of a combination of systemic and radiation therapy in patients with locally advanced non-small cell lung cancer (NSCLC). The high risk of latent metastasis in this category of patients sets the prerequisites for active research of the combination of radiation therapy and systemic treatment worldwide. The article presents the results of clinical studies aimed to find the most optimal ratio of efficacy and safety of the chemotherapeutic component of chemoradiotherapy (CRT). According to the results of the research, the authors prefer the use of schemes based on platinum doublets. The article discusses the evaluation of the effectiveness of chemoradiotherapy with escalation of the radiation dose to the tumor within the framework of the concept of a personalized approach to therapy of patients with NSCLC. The article also pays attention to the description of new possibilities for RT intensification and the introduction of new RT methods, the use of which became possible with the introduction of innovative linear accelerators. The results of comparing the effectiveness of combined chemoradiotherapy with immunotherapy and chemo radiotherapy alone in patients with lung NSCLC are presented.