LIPOXINS – THE CRUCIAL FACTOR FOR RESOLUTION OF INFLAMMATION

Abstract

Eliminating offending pathogens from the site of infection is an effective host defense mechanism resulting in subsequent resolution of inflammation restoring tissue homeostasis. Lipoxins are endogenous proresolving mediators which also have anti-inflammatory properties. Lipoxins play a crucial role in suppressing exaggerated tissue injury and chronic inflammation. Several studies demonstrated that synthesized lipoxin anolog has the ability to inhibit neutrophil recruitment and alter vascular permeability. This review explains lipoxins generation, its actions at the site of inflammation, its role in periodontal disease and how it could be used as a potential drug. KEY WORDS: Lipoxins, Defense mechanism, Inflammation, Resolution, Endogenous, Periodontal Disease