Impact of Evaporated AuNP Thickness on Pseudo-MOS and Its Application in Direct MicroRNA-375 Detection

Abstract

Different from traditional surface functionalization using organosilane coupling agents for probe DNA immobilization, this work develops the evaporated gold nanoparticle (AuNP) as the linker on silicon-on-insulator pseudo-MOS transistor. The electrical impact of AuNP thickness on pseudo-MOS is systematically studied by measuring the transfer characteristic curves. The AuNP/pseudo-MOS device is applied to immobilize probe DNA, and a label-free and direct detection of target microRNA-375 is achieved.