CPAP insufficiency leads to incomplete centrioles that duplicate but fragment

A. Vásquez-Limeta, Kimberly Lukasik, Dong Kong, Catherine Sullenberger, Delgermaa Luvsanjav, Natalie Sahabandu, R. Chari, J. Loncarek
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引用次数: 4

Abstract

Vasquez-Limeta et al. use human cells engineered for fast degradation of centrosomal protein CPAP. Using superresolution microscopy, they show that CPAP insufficiency leads to centrioles with incomplete microtubule triplets that convert to centrosomes and duplicate, but fragment owing to loss of cohesion between microtubule blades.
CPAP功能不全导致中心粒不完整,中心粒复制但断裂
Vasquez-Limeta等人使用经过工程改造的人类细胞快速降解中心体蛋白CPAP。使用超分辨率显微镜,他们发现CPAP不足导致中心粒具有不完整的微管三胞胎,它们转化为中心体并复制,但由于微管叶片之间的内聚性丧失而碎片化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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