[Liver function in newborn infants with conjugation hyperbilirubinemia after exchange transfusion and hemosorption].

Abstract

Overall 40 neonates with conjugation jaundice were examined. A study was made over time (after 1 and 5 days) of the content of bilirubin, cholesterol, total protein, cholyl glycine, cholinesterase, and alanine aminotransferase before and after surgical treatment (substitution transfusion and hemoperfusion). It has been established that substitution transfusion inhibits protein synthesizing liver function and raises the content of cholyl glycine. In the authors, opinion, this reduces the bilirubin-binding capacity of albumin and increases hepatocyte membrane permeability. Extracorporeal detoxication makes protein synthesizing liver function return to normal, minimizes the content of cholyl glycine, promoting the growth of the bilirubin-binding capacity of albumin.