Anti-inflammatory Activity of an Oil Derived from Perna canaliculus (New Zealand Green-lipped Mussel).

The Internet Journal of Alternative Medicine Pub Date : 2008-12-31 DOI:10.5580/c

N. Greenhill, P. Davis

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Abstract

Background: There is considerable evidence that the New Zealand green-lipped mussel has beneficial effects for the treatment of chronic joint conditions through its anti-inflammatory activity. A new oil product based on an extract from the mussel has been prepared and its efficacy and possible mechanism of action for alleviating joint conditions investigated. Method: The effect of the oil on the production of superoxide by activating primary rat neutrophils in culture was measured. The dose-response effectiveness of it in reducing the inflammatory response in pristane-induced rheumatoid arthritis in rats was assessed. The results were statistically significant in both cases. Results: The oil was shown to suppress superoxide production by activated neutrophils by 32% even when diluted 4000 fold. When administered orally to rats it significantly inhibited the development of rheumatoid arthritis even at doses as low as 125 mg per kg of food. Conclusions: This oil has a potent effect on the production of superoxide by activated neutrophils and also is a strong inhibitor of rheumatoid arthritis in rats, probably through its antiinflammatory activity.

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新西兰绿唇贻贝油的抗炎活性。

背景:有相当多的证据表明，新西兰绿唇贻贝通过其抗炎活性对治疗慢性关节疾病有有益的作用。以贻贝提取物为基础制备了一种新的油脂产品，并对其缓解关节疾病的功效和可能的作用机制进行了研究。方法:采用活化培养大鼠原代中性粒细胞的方法，测定其对超氧化物生成的影响。评估其在降低普里坦诱导的类风湿关节炎大鼠炎症反应中的剂量反应有效性。结果在两种情况下都具有统计学意义。结果:即使稀释4000倍，该油也能抑制活化中性粒细胞产生32%的超氧化物。当给大鼠口服时，即使剂量低至每公斤食物125毫克，也能显著抑制类风湿关节炎的发展。结论:这种油对活化的中性粒细胞产生超氧化物有强有力的影响，也是大鼠类风湿关节炎的强抑制剂，可能是通过其抗炎活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Internet Journal of Alternative Medicine

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