Improved Drug Delivery: Spray Freeze Dried Nano-Liposomal Inhaled Aerosols

Zhao-quan Wang, R. Löbenberg, L. Sweeney, J. Wong, W. Finlay
{"title":"Improved Drug Delivery: Spray Freeze Dried Nano-Liposomal Inhaled Aerosols","authors":"Zhao-quan Wang, R. Löbenberg, L. Sweeney, J. Wong, W. Finlay","doi":"10.1109/ICMENS.2004.80","DOIUrl":null,"url":null,"abstract":"A novel powder formulation for inhaled aerosol drug delivery of nano-liposomes has been prepared using spray-freeze drying. After saline reconstitution 91% of the liposome particles (mean volume size) were found to be smaller than 600 nm. Upon aerosol dispersion, a fine particle fraction (FPF) of more than 80% was achieved for this formulation with a model drug (ciprofloxacin) using a new passive inhaler (patent pending) at an inhalation flow rate of 60 l/min.","PeriodicalId":344661,"journal":{"name":"2004 International Conference on MEMS, NANO and Smart Systems (ICMENS'04)","volume":"26 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2004-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"2004 International Conference on MEMS, NANO and Smart Systems (ICMENS'04)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/ICMENS.2004.80","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1

Abstract

A novel powder formulation for inhaled aerosol drug delivery of nano-liposomes has been prepared using spray-freeze drying. After saline reconstitution 91% of the liposome particles (mean volume size) were found to be smaller than 600 nm. Upon aerosol dispersion, a fine particle fraction (FPF) of more than 80% was achieved for this formulation with a model drug (ciprofloxacin) using a new passive inhaler (patent pending) at an inhalation flow rate of 60 l/min.
改进的药物输送:喷雾冷冻干燥纳米脂质体吸入气溶胶
采用喷雾冷冻干燥的方法制备了一种用于雾化吸入给药的纳米脂质体粉末制剂。经盐水重构后,91%的脂质体颗粒(平均体积大小)小于600 nm。在气溶胶分散后,使用一种新的被动吸入器(专利申请中),以60 l/min的吸入流速,使用模型药物(环丙沙星),该配方的细颗粒分数(FPF)超过80%。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信