Immune Response and Memory: Perspectives on Stability of Cyclic Idiotypic Network

Abstract

Immune memory can be regarded as an equilibrium state of immune network system with nonlinear behavior. The rapid response of immune systems to the second-time antigen is owing to the stable structure of memory state forming by a closed loop of the idiotypic immune network. A dynamical system is proposed which explains how the memory state is formed and stabilized in the immune network.